Keep asking the wrong questions and we’ll never tame this pandemic

Experts, Public Health authorities and politicians are all the time asking the wrong questions.

Questions like: “Who shed more, the vaccinated or unvaccinated?” or “Who is better protected, the vaccinated or the unvaccinated?” are simply completely irrelevant when it comes to understanding the real challenge posed by this pandemic. Everyone should know by now that ALL of us could shed ‘more’ or ‘less’ virus than anyone else or could be ‘more’ or ‘less’ susceptible than anyone else, regardless of our vaccination status.

So, what are then the right questions to ask?

The right questions ‘they’ should be asking themselves is: “How can we impact viral infection/ transmission in ways that dramatically and durably reduce overall viral spread of more infectious Sars-CoV-2 variants in the population (i.e., in all of us)?” and “How can we impact host immunity in ways that dramatically and durably increase overall protection against disease in the population (i.e., in all of us)?”

The answer to both questions is actually rather straightforward and simply based on common sense:

Population-level viral spread in highly vaccinated populations could dramatically and durably be reduced by massive antiviral chemoprophylaxis of all healthy individuals, subsequently followed by enrichment of these populations with healthy, unvaccinated individuals (hence why we will need a baby boom and encourage the influx of young & healthy unvaccinated immigrants).

Population-level immune pressure in highly vaccinated populations could dramatically and durably be reduced by massive early treatment of all individuals contracting Covid-19 disease, which would (automatically) be followed by long-lived acquired immune protection.

Both of the above proposals will effectively contribute to building herd immunity, which is the one and only solution to tame a pandemic. Or are the stakeholders of the current mass vaccination program still convinced that – contrary to all scientific evidence – it is mass vaccination that will ultimately end up generating herd immunity and that the virus will spontaneously tone down its virulence, regardless of all immune and infectious pressure currently exerted by the increasingly vaccinated and virus-exposed population, respectively?

As the original pandemic is now more and more evolving towards a pandemic of more infectious Sars-CoV-2 variants, we have no choice but to immediately implement a pancontinental intervention with broadly effective antivirals and early multi-drug treatment. Given the enhanced evolutionary context of this pandemic, there is no longer any place for non-sterilizing vaccines, let alone for using such vaccines in mass vaccination campaigns.

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